Scientist - Protein Biochemistry
Company: BioSpace Recruitment Services
Location: Pasadena
Posted on: January 12, 2021
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Job Description:
BioSpace has been engaged to help our client, a venture backed
biotechnology company utilizing a novel spatially encoded screening
and optimization platform to develop treatments for historically
intractable causes of human disease, to bring a Protein Biochemist
to their team. The Company's platform technology provides
comprehensive, quantitative affinity binding data at a completely
unprecedented scale. Our internal development programs are focused
on oncology and immunology. In addition to these programs we also
work with leading pharmaceutical companies. Our platform is based
on fluorescent imaging of ultra-dense microarrays such that, via
thousands to millions of images, we can measure billions of
target/molecule interactions in a day, generating hundreds of
millions of dose-response binding curves. Position Summary: We are
seeking a highly motivated, creative, and experienced protein
biochemist. As an integral member of our biology group, the
candidate will lead the design, expression, purification, labelling
and analytical characterization of protein targets for use in our
affinity screens. The quality and purity of the proteins is
critical to the data output from our screens. The position will
report to the Head of Biology. The core responsibilities of this
job will be 1. Identify and design appropriate protein constructs
for targets of interest for screening on the company---s small
molecule arrays 2. Manage protein expression and purification
efforts at external CROs for a broad range of protein targets 3.
Perform analytical characterization and labelling of protein
preparations 4. Establish protein expression and purification
capabilities onsite as needed 5. Develop and execute high
through-put affinity, biochemical or activity assays to evaluate
hits from affinity screens 6. Work closely with scientists across
the company and communicate results at project team meetings
Experience and Qualifications Given the company---s size,
anticipated growth and fast-paced environment, the organization
requires a Scientist who is thoughtful, high energy and can partner
with the broader organization to further enhance our next
generation drug discovery capabilities. Part of the
organization---s success is nurtured by a hands-on work environment
where everyone is accountable, everyone is vested in a vision of
excellence, and everyone actively takes part in the success of the
business. We support a positive work environment comprised of
engaged employees who feel appreciated, recognized and free to be
creative. Qualifications include: -- PhD in the field of protein
biochemistry, enzymology and/or structural biology -- 5 years of
hands-on experience in protein synthesis, purification and
modification -- Broad experience in expressing recombinant proteins
in a variety of expression 2 systems and modern molecular cloning
techniques required -- Extensive hands-on experience in protein
purification using a variety of chromatographic techniques required
-- Hands-on experience in use of analytical/biophysical techniques
(HPLC, DLS, DSF, etc.) for assessing stability, solubility, and
oligomerization status of proteins required -- Experience with
binding affinity measurements (SPR) highly desired -- Experience in
structural biology (X-ray crystallography, NMR, Cryo-EM) highly
desired -- Experience with enzymology, protein-protein interaction
and/or DNA/RNAbinding proteins would be a plus -- Excellent
organizational, interpersonal and communication skills and can
thrive in a highly collaborative research environment --
Demonstrated technical proficiency, ability to troubleshoot to
solve problems and to deliver high quality data She/he will exhibit
the ability to work well under pressure to provide results in a
short timeframe. The company is looking for a highly responsive,
goal-oriented individual who will bring significant energy and
drive to solve complex technical problems and help us achieve our
mission to advance human health.
Keywords: BioSpace Recruitment Services, Pasadena , Scientist - Protein Biochemistry, Other , Pasadena, California
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